The OPERA project aims to develop an innovative Bio-cooperative Robotic Platform (PRoBio) for virtual reality rehabilitation tailored to the characteristics of the individual patient with Parkinson's Disease (MP) in order to optimize their autonomy and quality of life. PRoBio will integrate a service robot (TIAGo, PAL Robotics SL) and a modular system that will provide cognitive-motor rehabilitation exercises in virtual mode (VRRSS, Khymeia) on a monitor installed on the robot. PRoBio will present an advanced multimodal architecture that dynamically monitors the patient's cognitive-motor-emotional state to assess their performance and compliance with interaction with the robot and rehabilitation exercises. The VRRSS system will deliver visual and vocal feedback and TIAGo physical feedback with its robotic arm. Rehabilitation activities will then be performed under appropriate bio-cooperative conditions consistent with the readings and feedback.