Leader: Paola Costelli (UPO/UNITO); Other collaborator(s):
Sarcopenia is a major contributor of frailty, poor quality of life and hospitalization; thus, defining functional parameters and new markers able to early identify people at risk of frailty is relevant. Volunteers of the EPIC cohort (Task 3.3) and patients with comorbidities (Task 3.4) will be studied to: 1) assess circulating markers of muscle mass and function (GDF-15, FGF21, CAF, microRNAs); 2) monitor sarcopenia by body composition data, functional assessments and neuromuscular changes (surface electromyography); 3) elaborate data in 1 and 2 to obtain a model for stratification according to the risk of frailty; 4) based on risk stratification, design and test targeted interventions (exercise), also using technological tools (Task 3.2).
Brief description of the activities and of the intermediate results.
The activity of this task will start once the EPIC-Turin recall will start. However, researchers of this WP are helping in identifying through literature research possible biological markers of stratification of patients.
Main policy, industrial and scientific implications.
Not yet available.
Brief description of the activities and of the intermediate results.
The activity of this task will start once the EPIC-Turin recall will start.
Definition of a protocol for the literature research about possible biological markers of stratification of patients.
Main policy, industrial and scientific implications.
Not yet available.
Brief description of the activities and of the intermediate results.
The activity of this task will start once the EPIC-Turin recall will start. Starting of the literature research about possible biological markers of stratification of patients.
Main policy, industrial and scientific implications.
Not yet available.
Brief description of the activities and of the intermediate results
Definition of the protocol for the systematic review on the biological markers for the stratification of the patients for their risk of healthy ageing.
Main policy, industrial and scientific implications
Not yet available.
Not yet available.