The AGEING-EPIC project aims to identify biological, clinical, physical, psychological, and social markers useful for stratifying the population based on their probability of healthy ageing. These markers will be integrated into algorithms designed to flexibly classify individuals according to their ageing trajectories, with the ultimate goal of overcoming the limitations of current models for managing age-related complexity. The final algorithms will be used to generate ageing trajectory prototypes and provide a valuable tool for designing public health strategies that promote well-being and preserve health in older adults.
The project is structured across six work packages: WP1 focuses on reconstructing the longitudinal cohort using participants from the original EPIC-Turin study; WP2–WP5 are dedicated to identifying biological, clinical, physical, and neuro-psychological markers; and WP6 involves generating predictive algorithms to stratify older populations by risk of unhealthy ageing.
During the first reporting period (August–December 2024), the project concentrated on WP1 and its associated tasks in WP2–WP5, setting the foundation for the longitudinal cohort. Key activities included: defining protocols for recalling EPIC-Turin participants; developing a data entry platform (RedCap); preparing consent and recruitment materials; identifying still-living participants; and updating mortality follow-ups. Standard operating procedures were established for data collection and biological sample management across the four recruitment sites.
Specific protocols were developed for metabolic profiling (WP2), neurodegenerative risk assessment with a focus on Parkinson’s disease (WP3), physical testing for sarcopenia (WP4), and psychological and neuropsychological assessments (WP5). Multiple amendments to the existing EPIC protocol were submitted to the University Ethics Committee to accommodate new sub-cohorts and extended measures.
Operational delays were reported due to a late official project start date (26 August 2024) and administrative challenges related to PNRR funding procurement procedures. These issues affected the timely submission of ethics documentation and the purchase of materials, delaying recruitment activities and limiting initial participant engagement. Nevertheless, the research teams mitigated risks by finalising all preparatory protocols and training activities, ensuring readiness for the next project phase. No deviations from project objectives or content have been identified to date.