Leader: Fiorenzo Conti (INRCA); Collaborators: Alessandro Sale, Gabriele Chelini (CNR)
This WP has been effective in pursuing and advancing several projects including modeling stroke in aging and determining the impact of physical training, also in a mouse model of juvenile parkinsonism, the generation of a model of chronic kidney disease and multi-omics analyses in bats. The impact of prolonged systemic treatment with irisin in aged mice improves memory and spatial cognitive abilities, mimicking exercise-induced effects.