Leader: Giuseppe Puglise (UNIROMA), Sarah Damanti (UNISR); Other collaborator(s):
Impaired exercise capacity and reduced trainability can be considered early markers of aging, cardiometabolic disorders and physical disability. Assessing exercise capacity and its cardiorespiratory and neuromuscular determinants may predict adverse outcomes, aid in designing and implementing personalized training interventions and serve as a tool in evaluating the effect of therapeutic strategies in aging people with type 2 diabetes.
Brief description of the activities and of the intermediate results: The research protocol has been registered with clinicaltrials.gov and approved by the Ethics Committee of Sapienza University of Rome. Between November 2023 and March 2024, the contracts for study conduction between the Department of Experimental Medicine of Sapienza University of Rome, Sant'Andrea University Hospital of Rome, and Foro Italico University of Rome have been finalized. One research contract has been activated and another one will be activated by the end of April. The equipment has been set up and the study database has been organized. The recruitment procedures have been started and the first group of participants is going to perform the baseline assessments and to initiate the six-month exercise training program.
Main policy/industry/practice implications: We have drafted and submitted to the Local Ethics Committee the research project “Identification and proactive management of the frailty syndrome at the Casa della Salute "Le Piagge", Firenze, a monocentric prospective longitudinal cohort, non-profit, on people of 75 year-old.
The recruitment procedures have been continued. The research contract has started. External funding has been obtained for paying the insurance for study participants, as this cannot be paid with PNRR funds.
The first group of participants has performed the baseline assessments and initiated the six-month exercise training program.
Additional diabetic patients and nondiabetic controls have been recruited; they have performed the baseline assessments and initiated the six-month exercise training program. The previously enrolled participants have continued the exercise training program.
Coming soon