Leader: Patrizia Rovere-Querini (UNISR); Other collaborator(s):
DAMPs as novel targets to interfere with aging trajectories. The investigation of sarcopenia, a multifactorial determinant of age-related morbidity, and of underlying inflammaging circuits may disclose pathomechanisms and tools for risk stratification. Damage-associated molecular patterns (DAMPs), released by damaged/dying cells, are key mediators of sterile inflammation that hold potential as novel biomarkers, e.g., HMGB1, implicated in muscle waste in cancer patients, but still unexplored in age-related sarcopenia. We plan to study DAMPs as serum biomarkers, in association with functional and imaging-related correlates to stratify clinical phenotypes and predict sarcopenia, disability and frailty in a large cohort of geriatric patients.
Brief description of the activities and of the intermediate results: In November and December 2023 we participated in coordination meetings with the other Spoke 3 partners. Organization of the activities. Performance of the multidimensional geriatric evaluations and blood biobank. From January we performed the multidimensional geriatric evaluations and biobank of the community dwelling volunteers previously enrolled in the FRASNET study. This is the cohort in which we are going to study the biomarkers of inflammation.
Main policy, industrial and scientific implications: Better definition of targets that could interfere with ageing trajectories.
Due to budget constraints, we shifted from the initial plan to measure damage-associated molecular patterns (DAMPs) for stratifying aging trajectories. Instead, we will measure GDF-15 in conjunction with multidimensional geriatric evaluations to stratify clinical phenotypes and predict sarcopenia, disability, and frailty in a large cohort of older individuals.
We continue to perform multidimensional geriatric evaluations (including blood sample collection and biobanking) in a large cohort of geriatric and neurologic patients.
We continue to perform multidimensional geriatric evaluations (including blood sample collection and biobanking) in a large cohort of geriatric and neurologic patients. We have now completed 222 visits of participants previously enrolled in the FRASNET study and 51 patients affected by cognitive impairment.
We have started the dosage of GDF15 though the Ella method in 144 patients.
We continue to perform multidimensional geriatric evaluations (including blood sample collection and biobanking) in a large cohort of geriatric and neurologic patients.
We have completed the dosage of GDF15 though the Ella method in both geriatric and neurologic patients.
Publications
- Damanti S, De Lorenzo R, Citterio L, Zagato L, Brioni E, Magnaghi C, Simonini M, Ruggiero MP, Santoro S, Senini E, Messina M, Farina F, Festorazzi C, Vitali G, Manunta P, Manfredi AA, Lanzani C and Rovere-Querini P (2025). “Frailty Index, Frailty Phenotype and 6-year mortality trends in the FRASNET Cohort”. Front. Med. 11:1465066. doi: 10.3389/fmed.2024.1465066
- Damanti S, Senini E, De Lorenzo R, Merolla A, Santoro S, Festorazzi C, Messina M, Vitali G, Sciorati C, Rovere-Querini P. Acute Sarcopenia: Mechanisms and Management. Nutrients. 2024 Oct 10;16(20):3428. doi: 10.3390/nu16203428. PMID: 39458423; PMCID: PMC11510680.
- Damanti S, Citterio L, Zagato L, Brioni E, Magnaghi C, Simonini M, De Lorenzo R, Ruggiero M, Santoro S, Senini E, Messina M, Vitali G, Manunta P, Manfredi AA, Lanzani C, Querini PR. “Sarcopenic obesity and pre-sarcopenia contribute to frailty in community-dwelling Italian older people: data from the FRASNET study”. BMC Geriatr. 2024 Jul 31;24(1):638. doi: 10.1186/s12877-024-05216-6.
- Ruggieri E, Di Domenico E, Locatelli AG, Isopo F, Damanti S, De Lorenzo R, Milan E, Musco G, Rovere-Querini P, Cenci S, Vénéreau E .“HMGB1, an evolving pleiotropic protein critical for cellular and tissue homeostasis: role in aging and age-related diseases”. Ageing Res Rev. 2024 Dec;102:102550. doi: 10.1016/j.arr.2024.102550.
- Lipreri MV, Di Pompo G, Boanini E, Graziani G, Sassoni E, Baldini N, Avnet S. “Bone on-a-chip: a 3D dendritic network in a screening platform for osteocyte-targeted drugs”. Biofabrication. 2023 Sep 1;15(4). doi: 10.1088/1758-5090/acee23
- Damanti S, Citterio L, Zagato L, Brioni E, Magnaghi C, Simonini M, De Lorenzo R, Ruggiero M, Santoro S, Senini E, Messina M, Vitali G, Manunta P, Manfredi AA, Lanzani C, Rovere Querini P. DNA polymorphisms in inflammatory and endocrine signals linked to frailty are also associated with obesity: data from the FRASNET cohort. Front Endocrinol (Lausanne). 2024 Oct 11;15:1412160. doi: 10.3389/fendo.2024.1412160
Dissemination
- 2024, October, oral presentation “Association between frailty-related genetic polymorphisms and obesity in older adults: insights from the FRASNET study” 125th National Congress of the Italian Society of Internal Medicine, Rimini, Italy
- 2024, September, oral presentation “Fattori clinici e ambientali, stato funzionale e multimorbilità in età avanzata ” at the congress AGEVITY at Bocconi University, Milan
- 2024, May, oral presentation “Fat mass predicts frailty and sarcopenia: prospective data from the FRASNET study” at the General Meeting Age-It in Venice
- 2024, March, poster presentation “Muscle function and waist circumference predict frailty in Italian older individuals: assessing concordance among various frailty definitions in the FRASNET Study” Sarah Damanti, Patrizia Rovere-Querini, Università Vita Salute San Raffaele, Milan (Italy) at the 14th International Conference on Frailty and Sarcopenia Research Conference in Abulquerque, USA
- 2023, December, poster presentation “CITOCHINE E POLIMORFISMI NUCLEOTIDICI ASSOCIATI A FRAGILITÀ E SARCOPENIA: DATI DELLO STUDIO FRASNET” Sarah Damanti, Chiara Lanzani, Laura Zagato, Lorena Citterio, Paolo Manuta, Patrizia Rovere Querini at the 68th National Congress of the Italian Society of Geriatric Medicine