A screening and selection campaign will be launched for eligible patients aged between 50 and 80, in agreement with the Order of Doctors and Dentists at Sicilian general practitioners' clinics. Eligibility will be assessed on the basis of the following criteria. Inclusion: age between 50 and 80; test your memory>33; preserved functional autonomy; signing of informed consent. Exclusion: cerebrovascular disease, alcohol abuse, severe systemic diseases associated with cognitive decline, severe psychiatric disorders, known neurological diseases; oculomotor disorders in childhood; history of neoplasia < 5 years; previous diagnosis of glaucoma or retinopathy; previous diagnosis of hearing loss or vestibular disorders; orthopaedic disorders with gait disturbance. Within 10 days of the screening visit, all enrolled subjects will undergo: in-depth neuropsychological assessment, video oculography: the study of eye movements, saccades, anti-saccades, pursuit; OCT examination; tonal and vocal audiometric examination; movement analysis with video capturing procedures.
The DataCOG project has completed all necessary ethical approvals for WP1: CE Kore University (Prot. 26579, 22/11/2024), CE Catania 2 (Prot. 257/CEL, 13/12/2024) and substantial amendment for the inclusion of vEyes (Prot. 06/CEL, 15/01/2025). In WP2, participating GPs were identified, screening procedures were harmonised and over 100 eligible subjects were pre-selected. In parallel, the vEyes partner developed and tested an innovative hardware/software system based on YOLO11 Pose, LSTM and Transformer networks, validated in part against the G-Walk and Qualisys systems, and integrated with Tobii Eye Tracker 5 technology for the detection of motor and oculomotor parameters related to mild cognitive impairment. This phase produced video acquisition tools and preliminary algorithms ready for AI processing of clinical data. There has been an operational delay due to difficulties in acquiring certain equipment no longer available on the market (viewers, audiometer), which has been replaced with new models. Corrective actions include the use of devices already present in the centres, new orders in progress and the planning of additional evaluation sessions to make up for lost time. Progress is consistent with the overall schedule, with completion of the deliverables planned for WP1 and operational start of WP2, while WP3 is postponed but recoverable in the following quarter.