- Polypharmacy, defined as the simultaneous use of multiple drug therapies to treat one or more medical conditions, is a common consequence of multimorbidity in the elderly. Although polypharmacy may be necessary to effectively manage multiple medical conditions, it also carries significant risks, including drug interactions, side effects, non-adherence to treatment, and increased risk of adverse events. These risks are particularly pronounced in the elderly due to age-related physiological changes, such as alterations in metabolism and renal function, which affect drug absorption, distribution, and elimination. This project aims to address an increasingly relevant challenge in healthcare by providing innovative solutions to improve the care and well-being of patients with multiple diseases. This goal will be realized in a demonstrator, which will be validated on a population of about 300 subjects. The demonstrator will consist of an innovative platform, based on the Ubiquitous computing paradigm, which, taking into account all the fundamental research activity envisaged in the project, will enable innovative patient monitoring in both Day Hospital and dehospitalization regimes..