- Università degli Studi di Sassari
- The project aims to identify and characterize “metabolomic signatures” in response to a nutritional intervention based on the Mediterranean diet model and global muscle strengthening training in a cohort of individuals over 65 years of age and to associate these signatures with observed physiological-pathological phenotypes. A multidisciplinary approach involving measurement of specific physiological outcomes and metabolome analysis from plasma, urine, and extracellular vesicle samples isolated from plasma will be applied. A multidisciplinary pre- and post-intervention dataset including clinical, blood-chemical, body composition, nutritional, physical-motor performance, psycho-cognitive, and metabolomic data from plasma, urine, and EVs will be obtained.