- The Physical Exercise in Hemodialysis Patients in End Stage Kidney Disease PEHEDAL-ESKD project aims to conduct a Clinical Trial involving intradialytic motor and motor-cognitive training. It will be a prospective, open-label, three-arm, nonpharmacological intervention Study in patients with End Stage Kidney Disease (ESKD) undergoing tri-weekly cycles of dialysis at centers affiliated with the NefroCenter network.