Leader: Giovanna Boccuzzo (UNIPD); Other collaborator(s): Pietro Belloni (UNIPD), Annalisa Donno (UNIPD), Maurizio Nicolaio (UNIPD), Enrico Bovo (UNIPD), Margherita Silan (UNIPD)
Using longitudinal data coming from large population administrative registers, the task addresses the following broad research questions: i) proposal of vulnerability indicators in the life course which could be used to stratify population; ii) implementation of the stratification procedures both in terms of health and socio-economic conditions with different administrative health databases; iii) evaluation of the different stratification procedures in terms of adverse health outcomes; iv) socioeconomic characterisation of different strata within different longitudinal studies, and identification of the critical points in health, employment and social trajectories associated with vulnerable health conditions in old age; v) tools for implement stratification of population in local health authorities
Brief description of the activities and of the intermediate results
TOPIC: Measures of Frailty
- Detailed analysis by systematic reviews of measures of frailty (physical, social, and mental) and preparation of a book (in Italian) “Misurare la fragilità negli anziani. Metodi e strumenti a supporto delle politiche e della ricerca” (Measuring frailty in the elderly. Methods and tools to support policy and research) (edited by G. Boccuzzo, authors G. Boccuzzo, E. Bovo, M.Nicolaio, S. Mondini, G. Sebastianutto, A: Ghirardo, D. Vo, M. Silan), submitted to Franco Angeli, open access and peer-reviewed Series “Salute e Società” (Health & Society). Awaiting the Reviewers' response.
- Preparation of anonymized health administrative databases aimed at creating frailty indices that can stratify the population (done)
- Implementation of algorithms for estimating the prevalence of chronic diseases: collaboration with the Epidemiological Unit of the Department of Prevention of ULSS 6 "Euganea" to identify and estimate the prevalence of diseases and other conditions using administrative health sources. Identification of relevant sources and coding within sources (done)
- Analysis on frailty outcomes: analysis and selection of the best subset of outcomes. Evaluation of relationships between outcomes and availability at administrative health sources (in progress)
- Research on new statistical approaches for frailty indicators in elderly population. Study of innovative method for a multivariate frailty indicator based on a sensitivity/specificity combination using administrative data flow. Study of variables selection for frailty indicators with survey data (in progress)
TOPIC “Causal pathways between healthy ageing and individual, social and contextual variables”
- Disease mapping research on new statistical methods of disease mapping and spatial clustering. Development of new models for mortality pattern identification. On this topic, one article is under review (E Bovo, P. Belloni1, A. Sottosanti, G. Boccuzzo, Where are people dying the most? Detecting territorial patterns of high mortality risk: a case study from northeastern Italy, Population Health Metrics, under revision) and another will be submitted shortly. Organization of the session (accepted) “Advancements in Spatial Epidemiology and Disease Mapping” at the annual conference of the American Statistical Association (August 2024).
- Multiple treatments in causal inference. Research on techniques for multiple treatments in a causal framework. Development of the R library “MARMoT” (P.Belloni, A.Calore, M. Silan; https://cran.rproject.org/package=MARMoT)
- Invited presentation at the international conference Data Science for Social Research (https://dssr2024.unina.it/page1.html): A simulation study to compare marmot adjustment and template matching in a multiple treatment framework (P. Belloni, A. Calore, M. Silan), specialised session “Unraveling Complexity: Causal Inference in Social Sciences”, March 27, 2024, Naples.
- Creation of a Data base composed by detailed socio-economic information for several years of a population at territorial level (census/neighbourhood) in the province of Padova (Italy) with the aim of improving analyses in frailty, enabling the inclusion of social and economic variables in the modelling phase.
- Analysis of the role of social frailty on physical frailty and causal mediation approaches using SHARE survey. Research done, two scientific articles are being prepared.
- Research in frailty and ageing with the aim of assessing the life histories of a population and checking possible characteristics that may lead one person rather than another to a frail state. Study of models for longitudinal data in the presence of information censoring and the healthy survivor effect (in progress).
OTHER:
- Published (March 20, 2024) the Explorative announcement for the project analysis longitudinal health and socio-economic data and development of a project on "Aging in good health in a life history and intergenerational view." (ex Task 5.6)
- Collaboration with Task 5.4 (Mondini) in the study of batteries of instruments measuring cognitive decline and risk factors for decline, with particular reference to the role of work activity. The research is completed; the preparation of scientific articles is in progress.
Main policy, industrial and scientific implications
Frailty measure: Stratifying the population according to care needs is a key public health goal defined by the National Plan for Chronicity (NPC) (Ministry of Health, 2016), and the Sector Reform of the National Recovery and Resilience Plan (PNRR), Decree No. 77 - May 23, 202
Collaboration with ULSS6 Euganea (province of Padua) to use administrative health data to stratify the population according to care needs has led to the preparation of rigorous anonymization procedures in order to make administrative data available for research purposes. This activity will be one piece of the products of the AGE-IT Data Management Board.
The implementation of algorithms for estimating the prevalence of chronic diseases represents a topic of fundamental importance in public health and in the use of health administrative data. It involves complex algorithms that, from several administrative flows, can identify the presence of multiple conditions and diseases. The sharing of such algorithms is a key support to health planning.
The software produced and published in the CRAN library is free to use and available to the very wide audience of R users.
TOPIC: Measures of Frailty
Detailed analysis by systematic reviews of measures of frailty (physical, social, and mental) and preparation of a book (in Italian) “Misurare la fragilità negli anziani. Metodi e strumenti a supporto delle politiche e della ricerca” (Measuring frailty in the elderly. Methods and tools to support policy and research) (edited by G. Boccuzzo and A. Donno), submitted to Franco Angeli, open access and peer-reviewed Series “Salute e Società” (Health & Society). We have received the Reviewers' response, the book will be published after revisions that should be done within the end of October. In addition, an invited presentation in plenary session of a conference was made by invitation (see Outputs), and an article is being prepared.
Analysis on frailty outcomes: analysis and selection of the best subset of outcomes. Evaluation of relationships between outcomes and availability at administrative health sources. The work is concluded and was presented at the AGE-IT General Meeting (see Outputs).
The study continued with two innovative proposals and the validation and improvement of proposals already published by the research group (in progress). This study is related to the output “Creation of new tools for frailty assessment, to be used in different care settings”
TOPIC “Causal pathways between healthy ageing and individual, social and contextual variables”
- Disease mapping research on new statistical methods of disease mapping and spatial clustering. A new article has been submitted (see Outputs).
- Analysis of the role of social frailty on physical frailty and causal mediation approaches using SHARE survey. The article is being written.
- Research in frailty and ageing with the aim of assessing the life histories of a population and checking possible characteristics that may lead one person rather than another to a frail state. Study of models for longitudinal data in the presence of information censoring and the healthy survivor effect (in progress)
Conferences
- P. Belloni, E. Bovo, A. Sottosanti, G. Boccuzzo. Where are people dying the most? Detecting territorial patterns of high mortality risk: a case study from northeastern Italy. 35TH Reves meeting, 22-24 maggio 2024, Bogotá, Colombia
- M. Silan, G.Boccuzzo, A.Donno (2024) Measuring frailty in the elderly. Methods and tools to support policy and research. LX Riunione scientifica Società Italiana di Economia Demografia e Statistica “Salute, ambiente e disuguaglianze: istituzioni, imprese e società”, Milano, 22 maggio 2024. Plenary Session.
- M. Silan, M. Nicolaio, E. Banzato, G. Boccuzzo (2024) Unravelling the connections between adverse health outcomes related to frailty for a better understanding of frailty and ageing. Poster, General Meeting Age-It, 22-24 maggio 2024, Venezia
- E. Banzato, G. Boccuzzo, A. Roverato, A. Buja. (2024) The analysis of multimorbidity patterns via graphical models. General Meeting Age-It, 22-24 maggio 2024, Venezia
In the months of June, July and August, the work done was finalized, through the preparation of conference reports and the submission of articles to scientific journals (output "~3 scientific publications on new models and algorithms to better stratify the different degrees of vulnerability).
In August and September we worked on arranging the revised book “Misurare la fragilità negli anziani. Metodi e strumenti a supporto delle politiche e della ricerca” to be sent back to the Franco Angeli publishing house. The book is related to the output ”Guidelines for professionals on tools for identifying subjects at risk of frailty".
TOPIC: Measures of Frailty
We have concluded the analyses related to MS 4.4 "Validation of an innovative tool to detect and prevent frailty in old age", and we are preparing a detailed report on the construction of the frailty indicator and its validation.
In September, the tender for the recruitment of an IT figure was also released to support the finalization of the output "Creation of new tool for frailty assessment, to be used in different care settings"
OUTPUTS
Articles submitted / under review:
- A. Donno, A. Ghrirardo, G.Boccuzzo. The influence of Social Frailty on Physical Frailty in older adults: Evidence from SHARE Survey. Submitted to The Journals of Gerontology, Series B: Psychological Sciences and Social Sciences.
- A. Donno, M. Silan, G. Boccuzzo. Assessing Frailty in Older Adults: Strategies and Tools for Effective Policy and Research. Invited submission to Rivista Italiana di Economia Demografia e Statistica
- A. Sottosanti, P. Belloni, E. Bovo, G. Boccuzzo. Bayesian Mapping of Mortality Clusters, under revision in Biostatistics (preprint available on https://arxiv.org/abs/2407.19135).
Conferences:
- A. Sottosanti, P. Belloni, E. Bovo, G. Boccuzzo. (2024) Hierarchical Bayesian modelling for detecting and clustering mortality profiles in space, Joint Statistical Meetings (JSM), Portland, August, 3-8 2024
- M. Silan, M. Nicolaio, E. Banzato, G. Boccuzzo. Unraveling frailty: Starting from the outcomes. 2nd workshop SOFIA – SOcial and health Frailty as determinants of Inequality in Ageing, University of Padua, September 9-10, 2024.
- E. Cisotto, G. Cavrini, A. Ghirardo, G. Boccuzzo. Proposal for a Social Frailty Index. 2nd workshop SOFIA – SOcial and health Frailty as determinants of Inequality in Ageing, University of Padua, September 9-10, 2024.
- A. Donno, A. Ghirardo, G. Boccuzzo. The impact of social frailty on physical frailty in old age: a longitudinal study based on SHARE data. 2nd workshop SOFIA – SOcial and health Frailty as determinants of Inequality in Ageing, University of Padua, September 9-10, 2024.
- P. Belloni, S. Rebottini. Measuring frailty in old age population: a new indicator based on a combination of classifiers. 2nd workshop SOFIA – SOcial and health Frailty as determinants of Inequality in Ageing, University of Padua, September 9-10, 2024.
Work continued on the preparation of articles and the revision of the book “Misurare la fragilità negli anziani. Metodi e strumenti a supporto delle politiche e della ricerca”. The book is now accepted for publication from Franco Angeli publishing house and now undergoing proofreading.
A resource was recruited for the development of the ouput ‘Tools for measuring frailty in population’, which is working on the creation of a Shiny App for the calculation and tabular and graphical representation of the frailty indicator.
One article has been accepted and already published, others are still under revision and two were unfortunately rejected and are currently being resubmitted to other journals. New projects for the creation of frailty measures based on health administrative data and new master's theses were launched.
The first draft of the MS 4.4 Report "Validation of an innovative tool to detect and prevent frailty in old age" is ready, the final version will be delivered by the end of March 2025.
Writing of the paper “Protective and risk factors for cognitive decline: The role of Sex and Occupational Status” Sebastianutto, G., Salvi Bentivoglio, S., Montemurro, S., Pucci, V., Boccuzzo G., Mondini, S.
OUTPUTS
Published Articles:
- A. Donno, M. Silan, G. Boccuzzo (2024). Assessing Frailty in Older Adults: Strategies and Tools for Effective Policy and Research. Rivista Italiana di Economia Demografia e Statistica, Vol. LXXVIII-3 July-September 2024. DOI: https://doi.org/10.71014/sieds.v78i3.398. Freely available at https://www.rieds-journal.org/rieds/article/view/398.
Dissemination:
- Presentation of Spoke 4 to DigitalMeet 2024, Padova, October 24. https://digitalmeet.it/programma-2024/
- Presentation of AGE-IT to StatisticAll, Festival della Statistica e della Demografia, Treviso, October 20. In collaboration with LoLa (Laboratory of Longevity and Ageing). www.festivalstatistica.it.
- Measure and analysis of Social Frailty (A. Donno and G. Boccuzzo). Literature review on theoretical models of social frailty, with a specific focus on studies using SHARE data, with the aim of identifying both the theoretical framework and the key variables to be used for the development of a SHARE-based social frailty indicator. Analysis of the relationship between social frailty and healthcare utilization across different welfare regimes, by estimating models that considered both an overall indicator of social frailty and its individual components.
- Measure and analysis of Phisical frailty.
- Progress on the work on a new model-based frailty indicator using administrative data (P. Belloni, S. Rebottini and E. Bortolotto).
- Progress on the work on the joint analysis of mortality and frailty over the life course (E. Bovo and G. Boccuzzo).
- The MS 4.4 Report "Validation of an innovative tool to detect and prevent frailty in old age" is almost ready (M. Nicolaio, M. SIlan and G. Boccuzzo). It is a comprehensive report on frailty: it details all the steps involved in the construction of the frailty index, the validation analyses, its application within the ULSS 6 "Euganea" territory, and includes in-depth discussions on the methodologies used.
- Progress in the development of the tool for calculating the fragility indicator (A. Mavilla, M. Silan and G. Boccuzzo). The preparation of the tool, through the construction of a Shiny app, is continuing. The graphical interface and the algorithm for calculating the indicator are ready; functions for reporting the results are now being added. The testing of the application at ULSS6 Euganea (Padua) and ASL TO3 in Turin will follow.
- The activities of ULSS6, which has a contract in place with the Department of Statistical Sciences of the University of Padua (DSS) (G. Boccuzzo, M. SIlan and M. Nicolaio), continue. ULSS6 is preparing algorithms for the identification of chronic diseases and other health outcomes from administrative health flows. This will be followed by the anonymisation and provision of the agreed data.
- The collaboration with ASL TO3 (Turin), which has an existing contract with the DSS (G. Boccuzzo, M. Silan and M. Nicolaio), has entered into force. At this stage, ASL TO3 is validating the fragility indicator constructed by the DSS researchers with the data in their possession.
- Disease mapping: Progress on two disease mapping works, one submitted after the first round of review to Biostatistics, and the other submitted to Environmental and Ecological Statistics (P. Belloni E. Bovo, A. Sottosanti, and G. Boccuzzo).
- Collaboration with Task 5.3 for the analysis of the role of Cognitive Reserve on cognitive functioning along the lifespan (E. Bovo and G. Boccuzzo).
OUTPUTS
In press
- Revision of the first draft of the volume “Misurare la fragilità negli anziani. Metodi e strumenti a supporto delle politiche e della ricerca”, a cura di G. Boccuzzo e A. Donno, which has already been accepted for publication from casa edirtice Franco Angeli, che ha fornito la prima bozza per la stampa
Accepted
- Cisotto E., Donno A., Boccuzzo G., Social Frailty and Healthcare Utilization Among Community-Dwelling Older Adults in Europe. Accepted for publication in the IES (IES 2025: Innovation & Society: Statistics and Data Science for Evaluation and Quality). Book of short papers.
- Belloni P., Rebottini S., Measuring frailty in the elderly: an indicator based on a combination of classifiers. Accepted for publication in the IES (IES 2025: Innovation & Society: Statistics and Data Science for Evaluation and Quality). Book of short papers.
- M. Nicolaio, M. Silan, G. Boccuzzo. Sensitivity Intervals for a Frailty Indicator Based on partially ordered set theory. Accepted for publication in the IES (IES 2025: Innovation & Society: Statistics and Data Science for Evaluation and Quality). Book of short papers.
Under revision
- M. Silan, M. Nicolaio, G. Boccuzzo, “Profiling Frailty: A parsimonious Frailty Index from health administrative data based on POSET theory”. Submitted to International Journal of Population Data Science (under revision).
- M. Silan, M. Nicolaio, E. Banzato, G. Boccuzzo “Unraveling Frailty: Starting from the Outcomes”, submitted to Journal of Aging and Health (under revision).
- Donno A., Boccuzzo G., Understanding the Link Between Social and Physical Frailty in Older Adults: SHARE-based findings. Submitted to Genus. (under revision)
- A. Paoli, F. Lucidi, M. Illario, F. Pagnini, G. Boccuzzo, G. Iaccarino. Multidimensional determinants of active and healthy ageing trajectories: For the AGE-IT Spoke4 group. Submitted to The Journals of Gerontology, Series B: Psychological Sciences and Social Sciences (under revision)
- E. Bovo, P. Belloni, A. Sottosanti, G. Boccuzzo. A model-based scan statistic with enhanced specificity for detecting spatial clusters of high mortality risk. Submitted to Environmental and Ecological Statistics (under revision)
- G. Sebastianutto G., S. Salvi Bentivoglio, S. Montemurro, V. Pucci, G. Boccuzzo, S. Mondini. The Role of Occupational Status and Sex Differences: what protection for healthy ageing? Submitted to Journal of Ageing and Health (under revision).
Dissemination
G. Boccuzzo, PNRR Age-it: uno sguardo multidisciplinare sull’invecchiamento. Sessione Plenaria Disturbi neurocognitivi: tra prevenzione e cura. 25° Congresso Nazionale dell’Associazione Italiana di Neuropsichiatria, Padova, 25-27 March 2025.
G. Boccuzzo. Dalla misurazione alla prevenzione: la fragilità sanitaria come indicatore chiave nelle emergenze, con particolare riferimento al COVID-19. Relazione invitata, Workshop “Analisi causale delle determinanti dello stato di salute dei pazienti affetti da Long-Covid”, 10 febbraio 2025, Perugia.
At the end of the 30-month period, several outputs and milestones relating to Task 5.1 are expected.
This report first provides a scientific account of these outputs and milestones, before offering an overview of the overall activity in the April–June 2025 quarter.
Output: ~3 scientific publications on new models and algorithms to better stratify the different degrees of vulnerability (~M30)
These are the publications produced specifically on this topic:
- A. Donno, M. Silan, G. Boccuzzo (2024). Assessing Frailty in Older Adults: Strategies and Tools for Effective Policy and Research. Rivista Italiana di Economia Demografia e Statistica, Vol. LXXVIII-3 July-September 2024.DOI: https://doi.org/10.71014/sieds.v78i3.398. Freely available at https://www.rieds-journal.org/rieds/article/view/398. This article is part of the October-December 2024 report.
- M. Silan, M. Nicolaio, G. Boccuzzo. (2025) Profiling Frailty: A parsimonious Frailty Index from health administrative data based on POSET theory. arXiv:2506.23158 [stat.AP]. https://doi.org/10.48550/arXiv.2506.23158. Submitted to a scientific journal.
- S. Rebottini, P. Belloni (2025) Measuring frailty in the elderly: an indicator based on a super-classifier. arXiv:2506.22349 [stat.ME]. https://doi.org/10.48550/arXiv.2506.22349. Submitted to a scientific journal.
Other articles on this topic are being resubmitted:
M. Silan, M. Nicolaio, E. Banzato, G. Boccuzzo. Unravelling Frailty: Starting from the Outcomes. Under submission in Frontiers in Medicine.
The following volume was also published as an output “Guidelines for professionals on tools for identifying subjects at risk of frailty (M12)”:
Boccuzzo G. and Donno A. (Eds.) (2025). Misurare la fragilità negli anziani. Metodi e strumenti a supporto delle politiche e della ricerca. Franco Angeli, Collana Open Access “Health and Society”, ISBN-13 (15) 9788835179504. https://series.francoangeli.it/index.php/oa/catalog/book/1345. (in Italian)
The volume was delivered to the publishing house within the 12-month deadline. It was then proofread by two anonymous referees and revised by the authors and editors of the various chapters. The proofs were then sent to the publishing house for production, and the final printing in dated May 2025.
Output: creation of a new tool for frailty assessment, to be used in different care settings (M30).
We have produced a web application (a Shiny app with R software) in order to provide local health authorities with a tool able to measure frailty in the population aged 65 and over. The index is calculated using the methodology proposed by Silan et al. (2025; https://doi.org/10.48550/arXiv.2506.23158). The application is currently being validated by researchers at UNIPD and users at the local health authorities in Padua and Turin. A user manual is currently being prepared. The app has a simplified interface which makes the following operations easy to carry out:
- loading the data needed to calculate the indicator;
- calculation of the frailty indicator in the population;
- downloading of data, including the frailty indicator;
- Presentation of some basic statistics on the indicator;
- Analysis of the frailty indicator based on other variables (e.g. chronic diseases) according to a customised query. Graphical visualisation and download of results.
- Possibility to calculate the frailty indicator for new subjects not included in the initial database, download the new database, and perform the above analyses.
Milestone: Validation of an innovative tool to detect and prevent frailty in old age (M30).
A detailed and rich volume (made available in the AGE-IT Output Repository) has been produced that proceeds to validate the frailty indicator proposed by Silan et al (2025, https://doi.org/10.48550/arXiv.2506.23158). The volume (in Italian) consists of the following chapters:
- What frailty is and how it can be identified
- Proposal of an indicator of frailty based on administrative data
- Data description
- Choice of frailty outcomes
- Selection of the variables composing the frailty indicator
- Construction of the frailty indicator
- Validation of the frailty indicator
- Analysis of the population of ULSS6 Euganea
- Methodological insights
- Appendix
In addition, the validation of the indicator was also carried out on data from the Piedmont Region, thanks to a contract with Local Health Unit TO3. The indicator was recalculated on the administrative health data of the Piedmont region using the procedure adopted by Silan et al. from the beginning, in order to verify whether the variables constituting the indicator were the same and whether the performance was equally good. In addition, the indicator already proposed by Silan et al. was applied to the data of Piedmont, just as the indicator reconstructed in Piedmont was applied to the data of Padua. The validation (also delivered on the AGE-IT repository) gave excellent results, demonstrating the stability and validity of the proposed indicator.
Scientific activity in the period April-June 2025
The scientific activity was mainly focused on the completion of the outputs and milestones planned for the deadline of month 30 and outlined above. The activities were carried out by the researchers of Task 5.1 in collaboration with specially recruited IT experts, with regard to the output “creation of a new tool for frailty assessment”, and are proceeding with the experts of the local health authorities (LHU) of Padua and Turin, with whom ad hoc contracts have been drawn up. In addition, further studies are proceeding with the LHU of Turin to assess the risk factors of frailty with a view to studies of generations and socio-economic risk factors over the life course.
A second topic concerns the measure of social frailty and its relationship with physical frailty. The study of this topic has already been underway for some time, some publications have been made (e.g. chapter in the Franco Angeli volume) and presentations at conferences are being finalised in the submission of scientific articles.
A third topic concerns the construction and analysis of measures of cognitive decline. This area of research is proceeding together with colleagues from Task 5.3 (Prof. Mondini), and has resulted in presentations and submission of a first article, a second is in the submission phase.
A fourth topic concerns territorial and socio-economic differences in mortality and morbidity in old age. Two already submitted articles are being revised on this topic.
OUTPUTS
Publications
Published:
Boccuzzo G. and Donno A. (Eds.) (2025). Misurare la fragilità negli anziani. Metodi e strumenti a supporto delle politiche e della ricerca. Franco Angeli, Collana Open Access “Health and Society”, ISBN-13 (15) 9788835179504. https://series.francoangeli.it/index.php/oa/catalog/book/1345. (in Italian).
In this volume:
- G. Boccuzzo, A. Donno. Prefazione, pp. 9-14
- Donno, M. Nicolaio, M. Silan, G. Boccuzzo. Cos’è la fragilità dell’anziano e come può essere identificata. pp. 15-34.
- E. Bovo, G. Boccuzzo. Misure di fragilità sulla base di indagini di popolazione. pp. 35-86
- M. Nicolaio, A. Donno, G. Boccuzzo. Indicatori di fragilità sulla base di dati amministrativi. pp. 87-170.
- Ghirardo, G. Boccuzzo. La fragilità sociale. pp. 194-231.
- E. Bovo, A. Donno. La fragilità in Italia. pp. 232-268.
G. Boccuzzo, E. Bovo, M. Marisera, L. Salmaso (Eds.) (2025) IES 2025 - Innovation & Society: Statistics and Data Science for Evaluation and Quality. Book of Short Papers. Cleup sc “Coop. Libraria Editrice Università di Padova”. ISBN 978 88 5495 849 4. https://ies2025.sis-statistica.it/book-of-short-paper/
In this volume:
- Measuring frailty in the elderly: an indicator based on a combination of classifiers. P. Belloni, and S. Rebottini. Invited session IPS06 - Frailty in Aging Populations. pp. 132-139.
- Sensitivity Intervals for a Frailty Indicator based on partially ordered set theory. M. Nicolaio, M. Silan, and G. Boccuzzo . Invited session IPS09 – Interplay between multimorbidity and frailty: implications for health and aging. pp. 212-218
K. T. Dame, P. Belloni, U. Moretti, F. Scapini, M. Tuccori, A. R. Brazzale. “Exploring Ontology-Based Mining of ADRs”. In: E. di Bella, V. Gioia, C. Lagazio, S. Zaccarin (eds). Statistics for Innovation IV. Springer (2025). https://doi.org/10.1007/978-3-031-96033-8_63
Under publication:
E. Cisotto, M. Silan, G. Cavrini, A. De Rose "Old Age Informal Caring and Impact on Health among Adults in Italy". Solicited Session “Micro-level data for the analysis of mortality and health outcomes”. In: E. Di Bella, V. Gioia, C. Lagazio, S. Zaccarin (Eds.), Statistics for Innovation I – SIS2025 Short Papers: Plenary, SPecialized and Solicited Sessions. Italian Statistical Society Series on Advanced Statistics, Springer. https://sis2025.sis-statistica.it/conference-proceedings/.
Preprint:
M. Silan, M. Nicolaio, G. Boccuzzo. (2025) Profiling Frailty: A parsimonious Frailty Index from health administrative data based on POSET theory. arXiv:2506.23158 [stat.AP]. https://doi.org/10.48550/arXiv.2506.23158.
S. Rebottini, P. Belloni (2025) Measuring frailty in the elderly: an indicator based on a super-classifier. arXiv:2506.22349 [stat.ME]. https://doi.org/10.48550/arXiv.2506.22349.
Progress of other publications:
- Sottosanti, P. Belloni, E. Bovo, G. Boccuzzo. “Bayesian Mapping of Mortality Clusters”. Under second revision in Biostatistics.
- E. Bovo, P. Belloni, A. Sottosanti, G. Boccuzzo. “A model-based scan statistic with enhanced specificity for detecting spatial clusters of high mortality risk”. Under second revision in Environmental and Ecological Statistics.
- A. Donno, G. Boccuzzo. “Understanding the Link Between Social and Physical Frailty in Older Adults: SHARE-based findings”. Under revision in Genus.
- E. Cisotto, M. Moretti, M. Silan, J. Damiens, P. Belloni, K. Korhonen, P. Martikainen. “Mapping Social Health and Dementia Risk: A Register-Based Study of Older Adults in Finland”. Under revision in Social Science and Medicine.
- G. Sebastianutto, S. Salvi Bentivoglio Sveva, S. Montemurro Sonia, V. Pucci, G. Boccuzzo, S. Mondini. “Protective and risk factors for cognitive decline: The role of Sex and Occupational Status.” Under revision in Social Science and Medicine. Work in collaboration with Task 5.3.
- A. Paoli, F. Lucidi, M. Illario, F. Pagnini, G. Boccuzzo, G. Iaccarino. Multidimensional determinants of active and healthy ageing trajectories: For the AGE-IT Spoke4 group. Under second revision in Journal of Gerontology: Social Sciences. Work in collaboration with all WPs of Spoke4.
Talks at conferences
Presentations in plenary, invited, specialised or invited sessions
- G. Boccuzzo. The Approach of Social Statistics. Session: Research on ageing: a transdisciplinary view. PopDays, 15th Edition. Cagliari, June 4-6 2025. https://aisp-sis.com/popdays-2025/
- M. Silan, M. Nicolaio, G. Boccuzzo. Developing a Frailty Index from Administrative Data: A POSET Theory Approach. Conference SIS2025, Statistics for Innovation. Solicited Session “The burden of chronic diseases: costs, resources, and outcomes”, Genova, June 16-18, 2025. https://sis2025.sis-statistica.it/
- E. Cisotto, M. Silan, G. Cavrini, A. De Rose "Old Age Informal Caring and Impact on Health among Adults in Italy". Conference SIS2025, Statistics for Innovation. Solicited Session “Micro-level data for the analysis of mortality and health outcomes”, Genova, June 16-18, 2025. https://sis2025.sis-statistica.it/
- P. Belloni, S. Rebottini. Measuring frailty in the elderly: an indicator based on a combination of classifiers. Invited session IPS06 - Frailty in Aging Populations. Conference IES2025, Innovation & Society: Statistics and Data Science for Evaluation and Quality. Bressanone-Brixen, Italy, June 25-27, 2025. https://ies2025.sis-statistica.it/.
- M. Nicolaio, M. Silan, and G. Boccuzzo . Sensitivity Intervals for a Frailty Indicator based on partially ordered set theory. Invited session IPS09 – Interplay between multimorbidity and frailty: implications for health and aging. Conference IES2025, Innovation & Society: Statistics and Data Science for Evaluation and Quality. Bressanone-Brixen, Italy, June 25-27, 2025. https://ies2025.sis-statistica.it/.
- M. Silan. Opportunità emergenti per la stratificazione del rischio dell’uso secondario dei dati & criticità di sistema. Sessione: Dimensioni ed elementi dell’invecchiamento sano ed attivo durante il lifecourse. Convegno One health: sinergie Age-it tra discipline e organizzazioni per un invecchiamento di successo. Napoli, 23-24 giugno 2025. https://www.ahlnapoli.it/
- A. Donno. Frailty in Later Life: Rethinking Vulnerability through Interdisciplinary Lenses. Tavola rotonda: Approccio person-centered per servizi innovativi ed equi dedicati alla salute lifecourse: insights da Age-IT Convegno One health: sinergie Age-it tra discipline e organizzazioni per un invecchiamento di successo. Napoli, 23-24 giugno 2025. https://www.ahlnapoli.it/
Other Talks
- K. T. Dame, P. Belloni, U. Moretti, F. Scapini, M. Tuccori, A. R. Brazzale. Exploring Ontology-Based Mining of ADRs. Conference SIS2025, Statistics for Innovation. Contributed Session Functional data, network analysis, and risk modeling in health and sports, Genova, June 16-18, 2025. https://sis2025.sis-statistica.it/
- A. Donno, E. Cisotto, A. Ghirardo, G. Boccuzzo, G. Cavrini. Measuring Social Frailty: A New Tool for European Older Adults Based on SHARE Data. PopDays, 15th Edition. Cagliari, June 4-6 2025. https://aisp-sis.com/popdays-2025/
- M. Silan, G. Bernardinis. Social media use among older adults: a weighted analysis of Facebook survey data. PopDays, 15th Edition. Cagliari, June 4-6 2025. https://aisp-sis.com/popdays-2025/
Organisation of Conferences
G. Boccuzzo is co-chair of IES2025 Conference, Innovation & Society: Statistics and Data Science for Evaluation and Quality. Bressanone-Brixen, Italy, June 25-27, 2025. https://ies2025.sis-statistica.it/. M. Nicolaio, E. Bovo, M. Silan e P. Belloni are members of the Organizing Committee.
Giovanna Boccuzzo (Spoke 4) and Marco Sandri (Spoke 2), as scientific coordinators of AGE-IT in UNIPD, organised the Third AGE-IT Meeting of UNIPD, held on 14 and 15 May at the University of Padua. On that occasion, UNIPD researchers presented the results of their research.